News (Updated December 17, 2010)

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Routine HIV tests can save lives

By Miriam Stoppard 14/12/2010

Experts recently called for routine HIV tests in casualty wards and GP surgeries in areas where prevalence is high - roughly a quarter of primary care trusts in England .

The call came after research from eight pilot projects revealed high numbers of people with HIV are going undiagnosed.

Worryingly, one study of emergency hospital admissions found that only a quarter of undiagnosed HIV-positive patients were correctly targeted and diagnosed.

Normally I'm all for patients having as much choice in their own health as possible but there are cases where I believe there's something even more important at stake - the health of the population as a whole.

Diagnosing this potentially devastating condition early can make all the difference to the success of treatment.

Despite vast improvements in treatment over the past two decades, HIV still reduces life expectancy by 13 years in the UK , mainly because it's often diagnosed late.

The later it's caught, the more damage is done to the body and the harder (and more expensive) it is to treat. The virus destroys important parts of the immune system, eventually leading to pneumonia, organ damage, tumours and even brain damage.


And most importantly of all, the longer someone goes undiagnosed, the more likely they are to have unwittingly passed the infection on to someone else.

Last year the Health Protection Agency reported there were 86,500 people living with HIV in the UK but shockingly a quarter of those were unaware of their status.

Make no mistake, HIV is no longer a gay man's disease - half of all people needing HIV care in the UK were infected through heterosexual sex.

Don't assume the danger is abroad - in 2009, a third of all heterosexuals diagnosed with HIV were thought to have been infected in the UK .

I believe routine testing in high-risk areas would help stop the spread.

It was a similar policy that led to the vaccination programmes that eliminated smallpox.

Encouragingly, more than 95% of people questioned in casualty wards and GPs' surgeries agree routine testing is a good idea. So what are we waiting for?

 

U.S. considers new tools in global AIDS fight

Dec 14 2010

By Andrew Quinn

WASHINGTON (Reuters) - The U.S. global AIDS program may turn to new tools such as microbicide gels and pre-infection treatment to slow the epidemic in hard-hit countries, the program's director said on Tuesday.

Eric Goosby said the President's Emergency Plan for AIDS Relief (PEPFAR) was looking closely at both the gels, which can protect women against infection during sex and "pre-exposure prophylaxis (PrEP)," which involves giving AIDS drugs to people in high-risk groups before they are infected.

"We would support PReP in terms of high risk populations," Goosby, the U.S. Global AIDS coordinator, told Reuters, adding that various country approval plans were already under internal consideration.

Goosby said microbicide gels -- a focus of hope since a South African clinical trial this year showed at least one version lowered HIV infection rates -- could also play a part once full regulatory approval is obtained and more is understood about how they work.

"We haven't worked out the delivery system or the dosing or interval of application," Goosby said. "We are absolutely positioned to engage in it as soon as we know those."

Goosby spoke as PEPFAR signed a new five-year deal with South Africa to bolster its AIDS fight, signaling a deepening cooperation between Washington and a country once depicted as representing the wrong approach to the AIDS epidemic.

"We are here at a moment when South Africa is turning the tide against HIV/AIDS. It is exciting to see," said U.S. Secretary of State Hillary Clinton, who signed the five-year deal with South Africa 's visiting Foreign Minister Maite Nkoana-Mashabane.

Goosby said the agreement would commit the United States to working with South Africa as it identifies its own AIDS-fighting priorities, with an emphasis on helping to build up the country's overall medical infrastructure.

SOUTH AFRICAN TURNAROUND

The United States contributes around $560 million a year to South Africa under PEPFAR, and Goosby said funding levels were expected to remain roughly constant for the country, where 1,000 people die from AIDS-related illnesses each day.

"We have developed a level of trust that is extraordinary," Goosby said. "They are revealing needs and vulnerabilities, and their ability to move forward has allowed us to have a heads up on where their areas are that we can help."

South Africa was criticized under former President Thabo Mbeki, who questioned accepted AIDS science and failed to make life-prolonging AIDS drugs widely available.

Mbeki's successor, President Jacob Zuma, has taken a different approach, promising drugs to more people and fighting the deep social stigma attached to the disease.

South Africa has been approved for more than $300 million in support from the Global Fund for AIDS, Tuberculosis and Malaria and devotes more than twice that amount from its own budget to fighting the disease.

The addition of PrEP and microbicide gels could represent a potentially large new budget item for PEPFAR, the $18.8 billion program launched by former President George W. Bush, but Goosby said new efficiencies in both care and treatment were already streamlining the overall bill.

He said South Africa had proposed using PrEP to treat uninfected inmates in South Africa 's prisons -- a major vector for HIV -- while pilot projects elsewhere were looking at sex workers and men who have sex with men.

Last month researchers showed that Truvada, a once-a-day pill combining two Gilead Sciences Inc HIV drugs, markedly reduced the risk of men contracting HIV. Gilead 's tenofovir was also used in the South African study that showed a microbicide gel lowered the infection rate by 30 percent for women.

South Africa has sought to expand its purchase of generic drugs, and Goosby said the United States actively supported efforts by developing nations to buy cheaper versions of drugs to save money.

(Editing by Todd Eastham)

 

HIV rate rises for young gay men

Julia Medew

December 13, 2010

HIV infections are on the rise among young gay men in Victoria , prompting calls for more prevention campaigns to combat the virus.

Research published in the Medical Journal of Australia today says the number of gay Victorian men being diagnosed with HIV in their 20s has jumped from 36 in 2007 to 59 last year. This occurred while infections stabilised or dropped among gay men aged 30 and above.

Authors of the research from Melbourne 's Burnet Institute said several factors might be contributing to the trend, including rising rates of unprotected anal sex and the growing prevalence of other infections, such as syphilis and gonorrhoea, which increase the chance of bodily fluids mixing during sex.

Behavioural studies had also shown that as HIV had become easier to treat, gay men under 35 were more likely to have sex with more partners, while not knowing their own and their partners' HIV status, the authors said.

''It has … been suggested that younger gay men may be more susceptible to engaging in risky sexual behaviour because they are less concerned about the implications of HIV since the introduction of highly active antiretroviral treatment (HAART),'' the authors wrote.

Head of HIV and STI research at the Burnet Institute Mark Stoove said that as more HIV positive people continued to live longer with treatment, there was also a greater pool of people who could transmit the virus.

This came as more HIV positive and HIV negative men were making decisions about sex according to the chance of transmission, he said.

This could include the use of different sex positions or knowledge about how infectious the HIV positive partner was at a given time, according to recent tests.

Dr Stoove said these factors had changed the way gay men perceived HIV and the risks involved.

''The perception of risk around HIV has become shades of grey, whereas it used to be much more black and white with health promotion messages revolving around condom use … We need much more nuanced messages now around different ways to reduce risk,'' he said.

While overall infections began to drop at the beginning of this year (52 in the first quarter of the year, compared with 66 for the same quarter last year), Victoria's new Health Minister David Davis said his government would produce a new HIV strategy by the end of 2011.

''The long-term task of managing the incidence of HIV requires constant focus,'' he said.

Dr Stoove said although HIV had become easier to treat, there were many reasons to fear the virus, including emerging links to cancer and heart disease for those who live on treatment for long periods. Stigma in the community also persisted.

''It's certainly not something to take lightly,'' he said.

 

TB, HIV target out of reach, says study

14-Dec-2010

SOUTH Africa remains below target on reaching the Millennium Development Goal pertaining to tuberculosis and HIV-Aids, the 2010 South African Health Review says.

MDG 6 has as a target detecting at least 70percent of new sputum smear-positive TB cases and curing at least 85percent of these cases plus to reduce TB prevalence and death rates by 50percent relative to 1990 levels.

The authors of the SAHR review chapter on HIV-Aids and TB pointed out that mortality due to TB and treatment interruption remained high in South Africa .

They attributed this to the high HIV infection rates and weak "health care service delivery mechanisms".

Before the emergence of HIV, the Western Cape reported the highest rates of TB. However, in 2006 KwaZulu-Natal , with an antenatal HIV prevalence of 39,1percent, exceeded the national HIV incidence rate, reporting a TB prevalence rate of 1066 in a 100000 population. The province also had among the worst National TB Programme performance indicators.

The SAHR confirms that the challenges faced are substantial and include increasing caseloads in the face of over-burdened health infrastructure, extremely poor cure rates in some provinces, high mortality, high treatment interruption rates, high levels of TB-HIV co-infection, increased levels of multi-drug resistant TB and the emergence of extensively drug resistant TB.

Of the high burden TB countries, South Africa has among the highest estimated costs for TB. This is due mainly to two reasons: the enormous cost of maintaining about 8000 TB beds and the cost of diagnosing and treating drug resistant TB.

Other challenges facing South Africa's ability to meet the MDGs are high treatment interruption rates, late presentation of patients to health facilities, insufficient community engagement, the HIV epidemic and poverty.

The SAHR revealed that of the 2472 and 2572 cases of MDR-TB diagnosed in KwaZulu-Natal laboratories in 2005 and 2006, respectively, only 56percent in 2005 and 28percent in 2006 were treated in hospital. The remaining patients died while awaiting admission, were lost to follow-up or remained infectious in the community.

The former health department director-general Thami Mseleku defended the institutional model for years though it was not reaching the majority of those with drug resistant TB.

Under Health Minister Aaron Motsoaledi there has been a definite move towards decentralising the management of MDR-TB.

 


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